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  • VPS33A 抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW6424
    • 應(yīng)用 : 僅供科研使用
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中文名稱: VPS33A 抗原(重組蛋白)

英文名稱: VPS33A Antigen (Recombinant Protein)

別     名 VPS33A core subunit of CORVET and HOPS complexes; MPSPS

儲     存: 冷凍(-20℃)

相關(guān)類別:抗原

概     述

Fusion protein corresponding to C terminal 200 amino acids of human VPS33A

技術(shù)規(guī)格

Full name:

VPS33A core subunit of CORVET and HOPS complexes

Synonyms:

MPSPS

Swissprot:

Q96AX1

Gene Accession:

BC016617

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a tethering protein and a core subunit of the homotypic fusion and protein sorting (HOPS) complex. The HOPS complex and a second endosomal tethering complex called the class C core vacuole/endosome tethering (CORVET) complex, perform diverse functions in endocytosis including membrane tethering, RabGTPase interaction, activation and proofreading of synaptic-soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) assembly to drive membrane fusion, and endosome-to-cytoskeleton attachment. The HOPS complex controls endosome maturation as well as endosome traffic to the lysosome. This complex is essential for vacuolar fusion and is required for adaptor protein complex 3-dependent transport from the golgi to the vacuole. The encoded protein belongs to the Sec1/Munc18 (SM) family of SNARE-mediated membrane fusion regulators. Naturally occurring mutations in this gene are associated with a novel mucopolysaccharidosis-like disease.