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  • SHC1 抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號 : TW4898
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存：20
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中文名稱： SHC1 抗原（重組蛋白）

英文名稱： SHC1 Antigen (Recombinant Protein)

別     名： SHC adaptor protein 1; SHC; SHCA

儲     存： 冷凍（-20℃）

相關(guān)類別：抗原

概     述

Fusion protein corresponding to a region derived from 384-583 amino acids of human SHC1

技術(shù)規(guī)格

Full name:

SHC adaptor protein 1

Synonyms:

SHC; SHCA

Swissprot:

P29353

Gene Accession:

BC014158

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.