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021-54845833/15800441009
中文名稱：兔抗CBFA2T2多克隆抗體
英文名稱： Anti-CBFA2T2 rabbit polyclonal antibody
別 名： CBFA2/RUNX1 translocation partner 2; EHT; p85; MTGR1; ZMYND3
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： CBFA2T2
反應(yīng)種屬： Human, Mouse
標(biāo) 記 物： Unconjugate
技術(shù)規(guī)格
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Background: |
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. |
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Applications: |
ELISA, WB |
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Name of antibody: |
CBFA2T2 |
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Immunogen: |
Fusion protein of human CBFA2T2 |
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Full name: |
CBFA2/RUNX1 translocation partner 2 |
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Synonyms: |
EHT; p85; MTGR1; ZMYND3 |
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SwissProt: |
O43439 |
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ELISA Recommended dilution: |
5000-10000 |
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WB Predicted band size: |
67 kDa |
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WB Positive control: |
293T, Raji, Jurkat, HepG2 cell lysates |
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WB Recommended dilution: |
1000-5000 |
