小鼠抗GLUD1單克隆抗體

Background:

This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.

Applications:

ELISA, WB

Name of antibody:

GLUD1

Immunogen:

Fusion protein of human GLUD1

Full name:

glutamate dehydrogenase 1

Synonyms:

GDH; GDH1; GLUD

SwissProt:

P00367

WB Predicted band size:

61 kDa

WB Positive control:

HEPG2 whole cell lysate

WB Recommended dilution:

1000-5000