兔抗BTK(Ab-222)多克隆抗體

Background:

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.

Applications:

WB, IHC

Name of antibody:

BTK(Ab-222)

Immunogen:

Synthesized non-phosphopeptide derived from human BTK around the phosphorylation site of tyrosine 222 (A-L-Y(p)-D-Y).

Full name:

Bruton agammaglobulinemia tyrosine kinase

Synonyms：

AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1

SwissProt:

Q06187

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

76 kDa

WB Positive control:

Hela cells lysate

WB Recommended dilution:

500-3000