兔抗PRELP多克隆抗體

Background:

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Applications:

ELISA, IHC

Name of antibody:

PRELP

Immunogen:

Fusion protein of human PRELP

Full name:

proline and arginine rich end leucine rich repeat protein

Synonyms:

MST161; SLRR2A; MSTP161

SwissProt:

P51888

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer

IHC Recommend dilution:

100-200