兔抗MYOT多克隆抗體

Background:

This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Applications:

ELISA, WB, IHC

Name of antibody:

MYOT

Immunogen:

Fusion protein of human MYOT

Full name:

myotilin

Synonyms:

MFM3; TTID; TTOD; LGMD1; LGMD1A

SwissProt:

Q9UBF9

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil

IHC Recommend dilution:

50-300

WB Predicted band size:

55 kDa

WB Positive control:

Mouse skeletal muscle tissue lysate

WB Recommended dilution:

1000-5000