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中文名稱: 兔抗RAP1GAP多克隆抗體
英文名稱: Anti-RAP1GAP rabbit polyclonal antibody
別 名: RAP1 GTPase activating protein; RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII
抗 原: RAP1GAP
儲 存: 冷凍（-20℃）
宿 主: Rabbit
反應(yīng)種屬: Human, Mouse
相關(guān)類別: 一抗
標(biāo) 記 物: Unconjugate
克隆類型: rabbit polyclonal
技術(shù)規(guī)格
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Background: |
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
RAP1GAP |
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Immunogen: |
Synthetic peptide of human RAP1GAP |
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Full name: |
RAP1 GTPase activating protein |
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Synonyms: |
RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII |
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SwissProt: |
P47736 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer |
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IHC Recommend dilution: |
25-100 |
