中文名稱(chēng): MASP1 抗原(重組蛋白)
英文名稱(chēng): MASP1 Antigen (Recombinant Protein)
別 名: 3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1
相關(guān)類(lèi)別: 抗原
儲(chǔ) 存: 冷凍(-20℃)
概 述
Fusion protein corresponding to a region derived from 449-699 amino acids of humanMASP1
|
Full name: |
mannan binding lectin serine peptidase 1 |
Synonyms: |
3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1 |
Swissprot: |
P48740 |
Gene Accession: |
BC106945 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants. |