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  • TPMT 抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW18461
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存：90
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中文名稱：TPMT 抗原（重組蛋白）

英文名稱： TPMT Antigen (Recombinant Protein)

別      名： thiopurine S-methyltransferase; TPMTD

儲(chǔ)      存： 冷凍（-20℃）

相關(guān)類別： 抗原

概      述：

Fusion protein corresponding to a region derived from 1-245 amino acids of human TPMT


技術(shù)規(guī)格：

Full name:

thiopurine S-methyltransferase

Synonyms:

TPMTD

Swissprot:

P51580

Gene Accession:

BC005339

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.