小鼠抗DCTN1(N-term)單克隆抗體

Background:

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

Applications:

WB, IP

Name of antibody:

DCTN1(N-term)

Immunogen:

Fusion protein of human DCTN1

Full name:

dynactin subunit 1

Synonyms:

P135; DP-150; DAP-150

SwissProt:

Q14203

WB Predicted band size:

142 kDa

WB Positive control:

293T, Hela, MCF7 and K562 cell lysates

WB Recommended dilution:

500-2000