兔抗CBL(Phospho-Tyr674)多克隆抗體

Background:

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation.

Applications:

WB

Name of antibody:

CBL(Phospho-Tyr674)

Immunogen:

Peptide sequence around phosphorylation site of Tyrosine674 (A-I-Y(p)-S-L) derived from Human CBL.

Full name:

Cbl proto-oncogene, E3 ubiquitin protein ligase

Synonyms：

CBL2; NSLL; C-CBL; RNF55; FRA11B

SwissProt:

P22681

WB Predicted band size:

100 kDa

WB Positive control:

HepG2 cells lysates treated with Na2VO3

WB Recommended dilution:

500-1000