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021-54845833/15800441009
中文名稱： CISH 抗原（重組蛋白）
英文名稱：CISH Antigen (Recombinant Protein)
別 名： cytokine inducible SH2 containing protein; CIS; G18; SOCS; CIS-1; BACTS2
相關(guān)類別：抗原
儲 存： 冷凍（-20℃）
概 述
技術(shù)規(guī)格
Full name:
cytokine inducible SH2 containing protein
Synonyms:
CIS; G18; SOCS; CIS-1; BACTS2
Swissprot:
Q9NSE2
Gene Accession:
BC031590
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
