兔抗CARD8多克隆抗體

Background:

The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.

Applications:

WB

Name of antibody:

CARD8

Immunogen:

Fusion protein of human CARD8

Full name:

Caspase recruitment domain-containing protein 8

Synonyms：

CARD8; CARDINAL; DACAR; DKFZp779L0366; Dakar; FLJ18119; FLJ18121; KIAA0955; MGC57162; NDPP; NDPP1; TUCAN

SwissProt:

Q9Y2G2

WB Predicted band size:

49 kDa

WB Positive control:

K562 and Hela cells

WB Recommended dilution:

500-2000