兔抗POLR3H多克隆抗體

Background:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway By similarity.

Applications:

WB

Name of antibody:

POLR3H

Immunogen:

Synthesized peptide derived from internal of human RPC8.

Full name:

polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)

Synonyms：

RPC8; RPC22.9

SwissProt:

Q9Y535

WB Predicted band size:

23 kDa

WB Positive control:

K562 cells lysate

WB Recommended dilution:

500-3000