兔抗FLNA多克隆抗體

Background:

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

FLNA

Immunogen:

Fusion protein of human FLNA

Full name:

filamin A, alpha

Synonyms：

FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280

SwissProt:

P21333

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human colon cancer and Human brain

IHC Recommend dilution:

50-200

WB Predicted band size:

281 kDa

WB Positive control:

PC3, NIH/3T3 and HUVEB cells

WB Recommended dilution:

1000-5000