兔抗FGFRL1多克隆抗體

Background:

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

FGFRL1

Immunogen:

Fusion protein of human FGFRL1

Full name:

fibroblast growth factor receptor-like 1

Synonyms：

FHFR; FGFR5

SwissProt:

Q8N441

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human colon cancer and human cervical cancer

IHC Recommend dilution:

100-300

WB Predicted band size:

55 kDa

WB Positive control:

NIH/3T3 cells and human placenta tissue, lovo cells

WB Recommended dilution:

200-1000