兔抗ESR1 (Phospho-Ser118)多克隆抗體

Background:

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Applications:

WB, IHC, IF

Name of antibody:

ESR1 (Phospho-Ser118)

Immunogen:

Synthetic peptide of human ESR1 (Phospho-Ser118)

Full name:

estrogen receptor 1 (Phospho-Ser118)

Synonyms:

ER; ESR; ESR1; ESTR; ESTRA; Era; ESRA; NR3A1

SwissProt:

P03372

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100

WB Predicted band size:

66 kDa

WB Positive control:

MDA cells treated with Estradiol

WB Recommended dilution:

500-1000

Positive control:

MCF cells

Recommended dilution:

100-200