兔抗ESR1(Phospho-Ser102) 多克隆抗體

Background:

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

Applications:

WB, IHC

Name of antibody:

ESR1(Phospho-Ser102)

Immunogen:

Peptide sequence around phosphorylation site of Serine102(L-N-S(p)-V-S) derived from Human Estrogen Receptor-α.

Full name:

estrogen receptor 1

Synonyms：

ER; ESR; Era; ESRA; ESTRR; NR3A1

SwissProt:

P03372

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

66 kDa

WB Positive control:

Huvec cells lysates

WB Recommended dilution:

500-1000