兔抗ERBB4多克隆抗體

Background:

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Applications:

ELISA, IHC

Name of antibody:

ERBB4

Immunogen:

Synthetic peptide of human ERBB4

Full name:

erb-b2 receptor tyrosine kinase 4

Synonyms:

HER4; ALS19; p180erbB4

SwissProt:

Q15303

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human ovarian cancer and human tonsil

IHC Recommend dilution:

20-100