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中文名稱：兔抗RAD17多克隆抗體
英文名稱： Anti-RAD17 rabbit polyclonal antibody
別 名： CCYC; R24L; RAD24; HRAD17; RAD17SP
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： RAD17
反應(yīng)種屬： Human, Mouse
標(biāo)記物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. |
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Applications: |
ELISA, WB |
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Name of antibody: |
RAD17 |
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Immunogen: |
Fusion protein of human RAD17 |
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Full name: |
RAD17 checkpoint clamp loader component |
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Synonyms: |
CCYC; R24L; RAD24; HRAD17; RAD17SP |
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SwissProt: |
O75943 |
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ELISA Recommended dilution: |
1000-2000 |
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WB Predicted band size: |
77 kDa |
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WB Positive control: |
Lovo cells |
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WB Recommended dilution: |
200-1000 |
