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  • F7抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號 : TW16721
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存：40
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中文名稱： F7抗原（重組蛋白）

英文名稱： F7 Antigen (Recombinant Protein)

別      名： SPCA

儲       存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述

Fusion protein corresponding to a region derived from C terminal 250 amino acids of human F7

技術(shù)規(guī)格

Full name:

coagulation factor VII (serum prothrombin conversion accelerator)

Synonyms:

SPCA

Swissprot:

P08709

Gene Accession:

BC130468

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.