小鼠抗RING1單克隆抗體

Background:

This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.

Applications:

WB, IHC

Name of antibody:

RING1

Immunogen:

Fusion protein of human RING1

Full name:

ring finger protein 1

Synonyms:

RNF1; RING1A

SwissProt:

Q06587

IHC positive control:

Human colorectal cancer and Human breast tissue; Human colon tissue and Human prostate tissue

IHC Recommend dilution:

500-1000

WB Predicted band size:

42 KD

WB Positive control:

Jurkat, 293T, K562, HepG2, Hela, MCF7, A549, COLO205, U251 cell lysates

WB Recommended dilution:

500-2000