兔抗LZTFL1多克隆抗體

Background:

This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants.

Applications:

ELISA, WB, IHC

Name of antibody:

LZTFL1

Immunogen:

Fusion protein of human LZTFL1

Full name:

leucine zipper transcription factor-like 1

Synonyms:

BBS17

SwissProt:

Q9NQ48

IHC positive control:

Human gastric cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

35 kDa

WB Positive control:

Human transitional cells carcinoma tissue, 293T and A172 cells, human testis tissue and Hela cells

WB Recommended dilution:

500-2000