Fusion protein corresponding to a region derived from 718-950 amino acids of human ERBB4 |
技術(shù)規(guī)格
Full name: |
erb-b2 receptor tyrosine kinase 4 |
Synonyms: |
HER4; ALS19; p180erbB4 |
Swissprot: |
Q15303 |
Gene Accession: |
BC112199 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. |