購物車
幫助
021-54845833/15800441009
Fusion protein corresponding to a region derived from 1399-1698 amino acids of human CUL7
技術(shù)規(guī)格
Full name:
cullin 7
Synonyms:
3M1; KIAA0076; dJ20C7.5
Swissprot:
Q14999
Gene Accession:
BC033647
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. CUL-7 is highly expressed in fetal kidney and adult skeletal muscle in addition to abundant expression in fetal brain, and adult pancreas, kidney, placenta and heart. It is also detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts.
