兔抗IWS1多克隆抗體

Background:

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Applications:

ELISA, IHC

Name of antibody:

IWS1

Immunogen:

Synthetic peptide of human IWS1

Full name:

IWS1, SUPT6H interacting protein

SwissProt:

Q96ST2

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and human tonsil

IHC Recommend dilution:

25-100